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TIOSEBON Men's Slip On Loafers-Comfort Walking Shoes Driving Sne


TIOSEBON Men's Slip On Loafers-Comfort Walking Shoes Driving Sne


Product Description



TIOSEBON all designs still be inspired by travel, art and the people closest to their integration, the combination of clothing shoes and sports-style shoes together to continue in today's highly competitive footwear market to provide the most original fashion cutting-edge series.

TIOSEBON products feature technologically advanced designs and materials to improve the comfort and performance of shoes.

TIOSEBON pay much attention on premium quality and service, we focus on the Health and Excellence.

TIOSEBON is a pursuit of simple, natural, comfortable, fashionable shoe.

TIOSEBON add some natural and clever design, is full of novelty, happy, romantic and the feeling of happiness.

TIOSEBON positioning as serving the crowd of about 16-55 years's people, the main product-oriented is fast fashion and the trend of fashion.

"th" Women's Athletic Tennis Shoes "th" Women‘s Driving Shoes "th" Women's Casual Walking Shoes
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Men's Walking Shoes Women's Comfortable Casual Sneakers Men's Lightweight Fashion Sneakers
Lightweight ✓ ✓ ✓ ✓ ✓ ✓
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Type Slip-on Slip-on Lace-up Slip-on Slip-on Lace-up

TIOSEBON Men's Slip On Loafers-Comfort Walking Shoes Driving Sne

Since Jan 2010, Selleckchem products have been cited in 415 studies from top scientific journals.

Thirteen Nobel Prize winners have published 44 articles with Selleck products.


Michael Houghton

Won the Nobel Prize in Physiology or Medicine in 2020

James P. Allison

Won the Nobel Prize in Physiology or Medicine in 2018

Michael Rosbash

Won the Nobel Prize in Physiology or Medicine in 2017

Eric Richard Kandel

Won the Nobel Prize in Physiology or Medicine in 2000

Brian K. Kobilka

Won the Nobel Prize in Chemistry in 2012

  • Sci Rep, 2019, 9(1):382

    PubMed: 30674983

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  • Mol Cell, 2019, 75(1):53-65.e7

Robert Lefkowitz

Won the Nobel Prize in Chemistry in 2012

Aaron Ciechanover

Won the Nobel Prize in Chemistry in 2004

New Products

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S8944 G150 Others Others G150 is a potent and highly selective human cyclic GMP-AMP synthase (h-cGAS) inhibitor with IC50 of 10.2 nM.
S8913 TH5487 Others Others TH5487 is a selective active-site inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1) with IC50 of 342 nM.
S8938 KGA-2727 SGLT GPCR & G Protein KGA-2727 is a potent, selective, high-affinity inhibitor of sodium glucose cotransporter 1 (SGLT1) with Ki of 97.4 nM and 43.5 nM for human SGLT1 and rat SGLT1, respectively. The selectivity ratios (Ki for SGLT2/Ki for SGLT1) of KGA-2727 are 140 (human) and 390 (rat). KGA-2727 exhibits antidiabetic efficacy in rodent models.
S8939 Mizagliflozin SGLT GPCR & G Protein Mizagliflozin is a novel, potent, selective sodium glucose co-transporter 1 (SGLT1) inhibitor with Ki of 27 nM for human SGLT1. The selectivity ratio (Ki value for human SGLT2/Ki value for human SGLT1) of mizagliflozin is 303. Mizagliflozin shows the potential use for the amelioration of chronic constipation.
S7013 Guadecitabine (SGI-110) Others Others Guadecitabine (SGI-110) is a next-generation hypomethylating agent whose active metabolite decitabine has a longer in-vivo exposure time than intravenous decitabine.
S8812 CM272 DNA Methyltransferase Epigenetics CM-272 is a novel first-in-class dual reversible inhibitor of G9a (GLP) and DNMTs with IC50 of 8 nM, 382 nM, 85 nM, 1200 nM, 2 nM for G9a, DNMT1, DNMT3A, DNMT3B, GLP, respectively. CM-272 prolongs survival in in vivo models of haematological malignancies by at least in part inducing immunogenic cell death.
S9729 Visomitin (SKQ1) Others Others INT-777 (S-EMCA) is a novel potent and selective TGR5 agonist with EC50 values of 0.18 μM, 3.9 μM and 1.45 μM for WT TGR5, TGR5(N76A) and TGR5(Y89F) respectively.
S8500 BAY1125976 Akt PI3K/Akt/mTOR BAY 1125976 is a selective allosteric AKT1/2 inhibitor,exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models. BAY1125976 inhibits the activity of AKT1 (IC50 = 5.2 nM at 10 µM ATP and 44 nM at 2 mM ATP) and AKT2 (IC50 = 18 nM at 10 µM ATP and 36 nM at 2 mM ATP) very potently.Whereas BAY1125976 is almost inactive on AKT3 (IC50 = 427 nM at 10 µM ATP).
Tags: kinase inhibitors, tyrosine kinase inhibitors, enzyme inhibitors, protein inhibitors, proteins kinase inhibitors, small molecules, phosphatase inhibitors